Signaling cell surface receptors
Our main interest here is the structural biology of cytokine receptors and G protein coupled receptor (GPCR) complexes. These receptor families
constitute the main conduit for information transfer between cells and their environment and we seek to reveal the various mechanisms involved in transmembrane signal instigation through receptor conformational transitions and recruitment of signaling partner proteins. By establishing the structural framework of signal instigation through these receptors we aim to identify novel therapeutic strategies for a variety of human
pathologies.
Relevant publications:
Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. (2013). Full-length Ga(q)-phospholipase C-ß3 structure reveals interfaces of the C-terminal coiled-coil domain. Nat Struct Mol Biol. PubMed link
Mancour LV, Daghestani HN, Dutta S, Westfield GH, Schilling J, Oleskie AN, Herbstman JF, Chou SZ, Skiniotis G. (2012). Ligand-induced architecture of the leptin receptor signaling complex. Mol Cell. PubMed link
Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL Jr, Steyaert J, Kobilka BK, Sunahara RK, Skiniotis G. (2011). Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A. PubMed link
Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. (2011). Crystal structure of the ß2 adrenergic receptor-Gs protein complex. Nature. PubMed link
